Nodular sclerosis classical Hodgkin lymphoma (NScHL)

Granulomatous bone marrow involvement of Hodgkin lymphoma, nodular sclerosis type

Nodular sclerosis Hodgkin lymphoma with classic Reed-Sternberg cells.

A 15-year-old young man presented to the emergency department with a 3-week history of sharp left-sided chest pain, shortness of breath on exertion, and a low-grade intermittent fever. Chest radiograph revealed increased density in the upper left lobe, thus he was treated with antibiotics for query pneumonia. Although his fever subsided, the patient continued to have chest pain, and subsequentl...

GWAS Analysis of Young Adult Nodular Sclerosis Hodgkin Lymphoma

Rationale General Background NSHL is the most common subtype of Hodgkin lymphoma in young adults, comprising between 60-80% of the disease in this age group; it occurs equally in males and females, peaks in incidence in the early 20’s, and is associated with higher socioeconomic status and low prevalence of Epstein-Barr virus in the tumors (1,2). Although commonly classified together with the m...

Advanced-stage nodular lymphocyte predominant Hodgkin lymphoma compared with classical Hodgkin lymphoma: a matched pair outcome analysis.

Due to disease rarity, there is limited information regarding the optimal therapy and outcome for patients with advanced-stage nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Forty-two patients with NLPHL by the Revised European-American Lymphoma/World Health Organization classification with advanced-stage disease were identified and paired 1:2 with a matched control with classical Hod...

Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma.

We studied the genomic status of BCL6 in 23 cases of nodular lymphocyte predominance Hodgkin lymphoma (NLPHL) and 40 cases of classical Hodgkin lymphoma (cHL), using dual-color interphase fluorescence in situ hybridization (FISH). The BCL6 rearrangement was identified in 48% of NLPHL cases and was not detected in cHL cases. As a confirmation, sequential or simultaneous immunohistochemistry (IHC...